目的：用Meta分析（Meta-analysis）对中药汤剂口服治疗乳腺癌患者发生蒽环类药物化疗心脏毒性的情况进行综合分析，以期将中药汤剂作为为临床治疗乳腺癌蒽环类药物心脏毒性的治疗方法。方法：收集已公开发表的有关中药复方口服乳腺癌患者蒽环类药物化疗心脏毒性的临床疗效的临床随机对照试验，分析其选方用药规律，采用RevMan5.2对符合条件的研究进行Meta分析，评价中医药对乳腺癌患者蒽环类药物化疗心脏毒性的临床疗效。结果：符合纳入标准文献共10篇，总样本量648例。中医药+蒽环类药物化疗与单纯蒽环 类药物化疗对比，心电图改变的更少，其差异有统计学意义[风险比（odds risk，OR）= 0.23，95%可信区间（Confidenceintervals，CI）（0.16，0.34），P < 0.00001]。心功能下降更少，其差异有统计学意义[OR= 0.18，95% CI（0.09，0.37），P < 0.00001]。左心室收缩功能有所改善，其差异有统计学意义[均数差（mean difference，MD）=3.82，95% CI（0.29，7.36），P=0.03 < 0.05]，心肌酶谱和心肌肌钙蛋白T均有所改善。结论：中医汤剂具有一定的抗乳腺癌患者心肌蒽环类药物损伤的作用。

Objective: To analyze the curative effects of traditional Chinese herbal decoction on breast carcinoma patients in doxorubicin- induced cardiotoxicity by meta-analysis to provide evidences for doctors in treating breast carcinoma patients who were in doxorubicin- induced cardiotoxicity by traditional Chinese herbal decoction.Method: Published papers about the curative effects of traditional Chinese herbal decoction on doxorubicin-induced cardiotoxicity in breast carcinoma patients in clinical random control experiment were collected. To analyze the prescription rules and do meta- analysis in the eligible ones by the software RevMan5.2. Evaluate clinical effects of traditional Chinese medicine in treating breast carcinoma patients who were in doxorubicin - induced cardiotoxicity.Results: Ten references and 648 cases in total meeting eligibility criteria were included. Compared with pure anthracycline - based chemotherapy drugs, the breast carcinoma patients who received Anthracycline - based chemo therapy drugs with traditional Chinese medicine, their ECG changes less, their difference was statistically significant (OR=0.23, 95% CI (0.16, 0.16), P <0.00001). They had better cardiac function. the difference was statistically significant (OR=0.18, 95% CI (0.09, 0.09), P < 0.00001). Their left ventricular systolic function improved. Their difference was statistically significant (MD = 3.82, 95% CI (0.29, 0.29), P=0.03 < 0.05). The myocardial enzyme spectrum, cardiac troponin I and myocardial troponin T were improved. Conclusion: To some extent, decoction of Chinese herbal medicine has effects on breast carcinoma patients with myocardial anthracycline - based drugs damage.

国家自然科学基金委面上基金项目（81473676）：三黄煎剂基于Aurora激酶A 抑制调控乳腺癌细胞分裂与血管形成的实验研究，负责人：卞卫和；江苏省中医院高峰学术人才培养项目（y2018rc11）：创伤修复及乳腺病的研究，负责人：姚昶。