目的：观察枳葛口服液对酒精性肝病大鼠脂质代谢的影响。方法：以酒精灌胃加普通饲料造模酒精性肝病大鼠，干预组酒精灌胃同时给予不同剂量枳葛口服液，对照组酒精灌胃同时给予解酒灵口服液。12周后处死大鼠，检测血清ALT、AST、TC、TG及肝组织TC、TG含量。结果：相比正常组，除高剂量组外各组肝脏指数、血清ALT、AST、TC、TG及肝组织TC、TG含量均显著升高（P < 0.01或0.05），其中模型组和低剂量组升高最为明显（P < 0.01）。相比模型组，以上检测指标在高、中、低剂量组及对照组均有所下降，且下降趋势均相同， 即枳葛口服液高剂量组下降最为明显（P < 0.01），其次是中剂量组及对照组（P < 0.05），低剂量组降低最不显著。相比对照组，各指标仅高剂量组有显著性差异（P < 0.05）。结论：一定剂量枳葛口服液可通过改善脂代谢紊乱而抑制或降低酒精性肝病的发生。

Objective: To observe the effects of Zhige oral liquid on lipid metabolism in rats with alcoholic liver disease. Methods: Alcoholic liver disease rats were induced by alcoholic gavage plus normal diet. The intervention group was given different doses of Zhige oral liquid at the same time. The control group was given alcohol and oral administration of Jiejiuling oral liquid. After 12 weeks, the rats were sacrificed and serum ALT, AST, TC, TG and liver TC and TG levels were measured. Results: Compared with the normal group, the liver index, serum ALT, AST, TC, TG and liver TC and TG levels were significantly higher in the groups except the high dose group (P < 0.01 or 0.05), among which the model group and the low dose group had the most significant increase (P < 0.01). Compared with the model group, the above indicators were decreased in the high, medium and low dose groups and the control group, and the decreasing trend was the same. That is, the high dose of the Zhige oral liquid was the most significant (P < 0.01), followed by the middle dose group and the control group (P < 0.05). The decrease in the low dose group was the least significant. Compared with the control group, there were significant differences in the high-dose groups (P < 0.05). Conclusion: A certain dose of Zhige oral liquid can inhibit or reduce the occurrence of alcoholic liver disease by improving lipid metabolism disorder.

四川省科技厅泸州市政府泸州医学院联合课题（14ZC0041）：枳葛口服液的研制及开发研究，负责人：魏嵋；四川省教育厅自然科学基金重点项目（16ZA0201）：枳葛口服液预防大鼠酒精性肝损伤的作用机制研究，负责人：刘友平。