慢性萎缩性胃炎是临床消化系统的常见病、难治病，细胞凋亡是导致相关病理改变的重要原因。 中医药作为临床防治消化系统疾病的重要手段之一，对慢性萎缩性胃炎中的作用以及机制成为近年来研究的 重要方向。本文通过收集相关文献资料，在分析慢性萎缩性胃炎发病可能机制基础上，把握细胞凋亡这一关键 环节，重点从线粒体途径、死亡受体途径、内质网途径及相关途径中具体信号通路阐明分析近年来中医药对慢 性萎缩性胃炎胃黏膜细胞凋亡调控的研究现状，为进一步系统深入开展相关研究以及探索慢性萎缩性胃炎有 效中医药治疗方案提供一定思路。

Chronic atrophic gastritis (CAG) is a common and refractory disease of the digestive system in clinic. Apoptosis is the important reason which relates CAG pathological changes. As one of the important means of clinical prevention and treatment of digestive diseases, traditional Chinese medicine (TCM) in the role and mechanism of CAG related research has become an important direction in recent years. Based on the collection of related literatures and data, the paper analyzed the possible mechanism of CAG pathogenesis grasped the key aspect of apoptosis and clarified the research status of TCM on the regulation of gastric mucosal cell apoptosis in CAG in recent years through focusing on the specific signaling pathways in mitochondrial pathway, death receptor pathway, endoplasmic reticulum pathway. Through the above analysis, the paper provided some ideas for further systematic and in- depth research and explored CAG effective TCM program.

内蒙古科技厅自然科学基金面上项目（2014MS0842）：基于线粒体信号通路探究加味黄芪建中汤对慢性萎缩性胃炎大鼠胃黏膜细胞凋亡的调 控机制，负责人：李永乐；内蒙古医科大学科技百万项目（YKD2017KJBW005）：基于TRAIL通路探究加味黄芪建中汤对慢性萎缩性胃炎大鼠 胃黏膜细胞增殖与凋亡失衡的影响及机制，负责人：李永乐；内蒙古医科大学人才团队自然科学项目（NYTD-2017006）：内蒙古医科大学中医 临床实训人才团队，负责人：李永乐；内蒙古医科大学科技百万（联合）重点项目（YKD2016KJBW(LH)025）：SDF-1/CXCR4生物轴调控胃癌侵 袭转移的分子机制研究，负责人：张锐。