目的：应用2001牛津循证医学中心临床证据分级评价2011-2015年中医类双核心期刊杂志文章中药治疗脑卒中的证据等级分布情况，对临床应用中药治疗脑卒中临床研究证据进行详细评价，以期为临床治疗脑卒中循证用药提供依据。方法：选择2014年最新北大图书馆中国中文核心期刊目录和最新2015-2016年CSCD目录共有的双核心中医类期刊共计19种为目标期刊，以电子检索和手工检索的形式检索，包括中国知网数据库、中国期刊全文数据库、中国生物医学文献数据库网络版、重庆维普中文科技期刊数据库、万方数据库和中国中医药期刊文献数据库在内的国内各大中文数据库，交叉检索以防漏检或误检。全部数据库检索时间从2011年1月1日至2015年12月31日。由2位研究员依照纳入与排除标准筛选文献，按照2001牛津循证医学中心临床证据水平分级进行证据分级评价，独立评价完成后，进行交叉核对，对有分歧者通过讨论或者第三者协调最终达成共识。最后分别计算各证据等级文章数目、百分比。结果：研究所纳入的目前中药治疗脑卒中临床研究证据主要集中在Ⅱb类、Ⅲb类，分别占36.4%和51.6%，而证据等级级别最高的Ⅰ类证据仅占9%，包括Ⅰa类6%，Ⅰb类3%，此外还包括少量Ⅳ类证据，占3%。所有纳入文献中干预措施使用补阳还五汤加减的文章有7篇，使用益气活血类中药的文章有5篇，使用凉血通瘀方的文章有7篇。结论：基于2001牛津证据等级分级分析可以发现目前中药治疗脑卒中临床研究证据等级级别仍然有待于进一步提高。活血化瘀仍然是治疗脑卒中不可忽视的方法。

Objective：Application 2001 Oxford evidence-based medicine center clinical evidence grading evaluation of traditional Chinese medicine (TCM) in 2011-2015 dual core journals magazine articles of traditional Chinese medicine treatment of cerebral stroke the distribution of the level of evidence, and the clinical application of Chinese medicine treating cerebral apoplexy clinical research evidence evaluation in detail, For the clinical treatment of cerebral apoplexy provide basis for the establishment of evidence-based medication guide. Methods：Choose the Chinese core journals in2014, the latest of Peking University library catalogue and the latest CSCD directory from 2015 to 2016 there were a total of 19 species of dual core of traditional Chinese medicine journals for the target journal, Retrieved in the form of electronic retrieval combined with manual retrieval, including Chinese Journal Full- text Database, China National Knowledge Infrastructure, Chinese Bio Medical Literature on disc, VIP Database, Wan Fang database, Traditional Chinese Medicine database. All of the database retrieval time from January 1, 2011 to December 31, 2015. By the 2researchers according to include and exclude standard screening of literature, And according to the 2001 Oxfordevidence-based medicine center clinical evidence classification of levels of evidence classification. Result：According to include and exclude standards, a total of 33 articles, into a randomized controlled trial of these articles (36.4%), arandomized controlled trial (48.6% ), systematic review/meta- analysis (6% ), a randomized controlled trial study accounted for 3%, 6% were retrospectively analyzed; Institute in Chinese medicine for treating stroke clinical research evidence mainly concentrated inⅡb, Ⅲb, 36.4% and 51.6% respectively, and the highest level of evidence levelⅠtypeaccounted for only 9% of evidence, includingⅠa type 6%,Ⅰb type 3%, moreover also includes a small amount of Ⅳtype, accounting for 3%. Conclusion: This study based on 2001 level of evidence classification of Oxford found that Chinese medicine treatment of cerebral apoplexy clinical research level of evidence level is not high.

新疆自治区科技厅面上项目(2015211C010)基于代谢组学的SHR、SHR-SP大鼠代谢性标记物及活血化瘀复方中成药干预的研究；负责人：吕光耀国家自然科学基金地区基金项目(81660787)新疆维吾尔族急性缺血中风血瘀证的microRNA表达机制研究；负责人：吕光耀。