现代中药创智研究只有在不同的研究阶段解决了不同的问题和挑战，才能成功登顶绝对海拔 8844.43米的世界之巅，研发出创新药物。针对此世界性难题，笔者团队基于传统中医药理论，构建了化学分子 辨识、因果数理模型辨识、药物分子功能辨识、功效辨识集成技术的“良关系”之效应物质辨识分析体系，着重 剖析复方药物-机体代谢网络及核心效应物质，从宏观到微观再到宏观阐释复方中药的药效物质基础和作用机 制，诠释“方成无药”的科学内涵。基于此融合中西医药优势提出了组合中药分子化学药物设计思路——“合策 略”，为新药创制提供了一种全新研究思路。

To better explore innovative drugs, the innovative and sapiential study of modern Chinese medicine has to face diverse challenges and try to solve various problems in different research stages. It is akin to reaching the top of Mount Qomolangma which is at the absolute altitude of 8844.43 meters. The identification analytical technology system was established by the authors research team, which inherited the essence of traditional culture and was based on the Traditional Chinese Medicine (TCM) theory of‘Jun- Chen- Zuo- Shi’. This technology system integrated chemical molecular identification technique, cause- effect mathematical model identification technique, activity identification technique and efficiency identification technique. It was employed to discovering the substance basis and elaborating their corresponding action mechanisms of TCM from macroscale and microscale perspectives, focused on studying the metabolic network of TCM compound and discovering the core "effector-response" substances of Jun-Shi herb pairs of ‘Liang Guanxi’. It is helpful to understand the scientific connotation of‘Fang-Cheng-Wu-Yao’. The combination strategy of TCM molecular chemistry was proposed and established, and might be a new study pattern for developing new drug.

陕西省科技厅重点研发计划（2017zqcxl-sf-01-02-01）：抗心肌缺血1 类化学新药丹参素异丙酯临床前研究，负责人：郑晓晖；国家教育部创新 团队发展计划（IRT_15R55）：基于秦巴优势生物资源的生命效应分析与新药创制研究团队，负责人：郑晓晖；国家科技部重大科学仪器设备开 发专项课题（2013YQ17052509）：超临界流体色谱在中药组方及其代谢物中的应用研究，负责人：郑晓晖；国家科技部“重大新药创制”科技重 大专项（2009ZX09103-121）：抗脑缺血1类化学新药DBZ的开发，负责人：郑晓晖；陕西省科技厅重点研发计划（2017SF-314）：干预糖脂代谢 紊乱的山楂叶关键黄酮成分的研究与开发，负责人：赵晔；国家自然科学基金委青年基金项目（81603259）：基于微透析-代谢组学-因果辨识 数理模型的丹参-降香抗脑缺血再灌注损伤的效应物质研究，负责人：贾璞。