铁死亡概念是Dixon等在Cell杂志上首次提出，定义为铁依赖的，脂质过氧化物生成所致的一种新型细胞死亡方式。铁死亡是神经系统疾病如AD、PD等的损伤机制，癌症发病过程中出现铁离子聚集，诱导铁死亡是癌症治疗的新型靶点。本文系统介绍铁死亡机制及与疾病治疗的研究进展，为疾病发生机制研究和临床药物靶点提供新思路。

The concept of iron death was first proposed in Cell magazine. It was defined as a novel cell death pattern caused by iron peroxide-dependent lipid peroxide formation. Iron death is the damage mechanism of some nervous system diseases such as AD and PD. Iron ions accumulate in the process of cancer development, and leading to ferroptosis is a new target of cancer treatment. In this paper, the mechanism of ferroptosis and the research progress of the diseases are introduced systematically, which provide new ideas for the research on pathogenesis of diseases and clinical drug targets.

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