微小病变肾病(minimal change disease，MCD)又称类脂性肾病，是导致肾病综合征的最常见病理类型之一，对激素敏感但极易复发，反复发作后可能对激素依赖或耐药，从而影响预后。MCD属中医学“水肿”“尿浊”“腰痛”“癃闭”之范畴，其发病与肺、脾、肾三脏功能失调有关。在治疗MCD方面，杨霓芝教授有着深厚的造诣，使用中医药改善MCD患者中大量蛋白尿、低蛋白血症、高度水肿的临床症状有一定疗效，配合激素治疗，可减轻药物副作用，提高疗效，降低复发率和不良反应发生率。

Minimal change disease (MCD), also known as lipid-induced nephropathy, is one of the most common pathological types of nephrotic syndrome. It is sensitive to hormones but is highly recurrent. It may be hormone-dependent or resistant after repeated episodes, Influencing prognosis. MCD belongs to the category of“edema”“urine turbidity”“low back pain”and“stagnation”in Chinese medicine. Its pathogenesis is related to the dysfunction of lung, spleen and kidney.Professor Yang Nizhi has a profound knowledge in the treatment of MCD. The use of traditional Chinese medicine to improve the clinical symptoms of massive proteinuria, hypoproteinemia and high edema in MCD patients has a certain effect. With hormone therapy, it can reduce the side effects of drugs and improve the curative effect. Reduce the rate of recurrence and the incidence of adverse reactions.