目的：观察清肺通络汤对肺炎支原体肺炎（Mycoplasma Pneumonia，MPP）患儿中医证候积分及血清炎性因子水平的影响，进一步明确通络法治疗MPP的临床疗效及优势。方法：将80例MPP患儿随机分为治疗组与对照组，每组各40例。治疗组采用阿奇霉素单程疗法联合中药清肺通络汤内服，对照组采用阿奇霉素序贯疗法，两组疗程均为20天。分别于治疗第0、7、14、20天应用中医证候评分量表进行疗效评定，同时测定治疗前后血清IL-6、IL-10水平。结果：①中医证候疗效比较：治疗组的愈显率为95%，对照组的愈显率为75.00%；两组在治疗7、14、20天时的中医证候疗效差异均具有统计学意义（P < 0.05），治疗组疗效优于对照组；②证候积分比较：治疗第7、14、20天治疗组中医证候总积分明显低于对照组（P < 0.05）。两组患儿治疗后的主症及次症评分均较治疗前明显降低，且治疗组患儿第20天咳嗽、痰壅、口渴评分低于对照组（P < 0.05）；③血清炎性因子水平比较：治疗组治疗后IL-6、IL-10水平均明显下降（P < 0.05），且治疗后治疗组IL-6、IL-10水平明显低于对照组（P < 0.05）。结论：清肺通络汤可有效改善MPP患儿的中医证候评分，降低血清炎性因子水平，临床疗效确切。

Objective: to observe the effect of Qingfei Tongluo Decoction on TCM syndrome score and serum inflammatory factors in children with mycoplasma pneumonia (MPP), and further to clarify the clinical efficacy and advantages ofTongluo therapy for MPP. Methods：a total of 80 children with MPP were randomly divided into the treatment group andthe control group, with 40 cases in each group. The treatment group was treated with azithromycin single course combinedwith Qingfei Tongluo Decoction and the control group with Azithromycin Sequential therapy. The two groups were treatedfor 20 days. In the zeroth, seventh, fourteenth and 20 days of treatment, the TCM Syndrome Scale was used to evaluatethe curative effect, and the levels of serum IL-6 and IL-10 before and after treatment were measured. Result：① Thecurative effect of TCM syndrome: the healing rate of the treatment group was 95% and the rate of the control group was75%. The two groups in the treatment of 7, 14, 20 days of TCM syndrome differences were statistically significant (P <0.05) and the treatment group was better than the control group; ② Syndrome score comparison: the total score of TCMsyndrome in the treatment group in the seventh, fourteenth, twentieth days was significantly lower than that of the controlgroup (P < 0.05). The scores of main symptoms and secondary symptoms in the two groups were significantly lower thanthose before treatment, and the cough, sputum and thirst scores on the twentieth day in the treatment group were lowerthan those in the control group (P < 0.05); ③ The level of serum inflammatory factors: after treatment, the levels of IL-6and IL-10 in the treatment group were significantly decreased (P < 0.05), and the levels of IL-6 and IL-10 in thetreatment group were significantly lower than those in the control group (P < 0.05). Conclusion：Qingfei TongluoDecoction can effectively improve the score of TCM syndrome in MPP children and reduce the level of seruminflammatory factors, with accurate clinical effect.

上海市科委科研基金资助项目（14401930300）：清肺通络汤治疗儿童肺炎支原体肺炎疗效评价，负责人：肖臻;上海市卫生计生系统重要薄弱学科建设计划项目（2016ZB0103-02），负责人：姜之炎；上海市申康医院发展中心市级医院新兴前沿技术联合攻关项目（SHDC12014110）：中西医结合治疗儿童支原体肺炎诊疗方案规范化研究,负责人：肖臻。