川贝母为我国传统名贵濒危高原药材，主要来源于野生，采挖过度导致野外资源已处于濒危状态。由于川贝母生长环境相对狭窄，生态环境脆弱，生长年限较长，导致生产管理难度大、病虫害严重、产量低，管理不当将会导致农药残留量超标。通过川贝母集约化“二段式”育苗技术，可以显著降低前期管理成本，提高大田及野生抚育成活率，缩短生长周期，提高产量及质量。本文对川贝母无公害栽培的关键环节，包括产地环境选择、新品种选育、“二段式”育苗技术、综合农艺管理、野生抚育模式、采收加工等进行了概述，为川贝母无公害生产提供保障。

Fritillaria cirrhosa D. Don is a traditional Chinese valuable and endangered plateau medicinal material,mainly from the wild. Excessive excavation leads to the endangered state of wild resources. The relatively narrow growthenvironment of F. cirrhosa, fragile ecological environment and long growth period, lead to difficult productionmanagement, serious pests and diseases, and low yield. Improper management will lead to excessive pesticide residues.Through the intensive "two-stage" seedling technology of F. cirrhosa, the cost of pre-administration can be significantlyreduced, the survival rate can be improved, the growth cycle can be shortened, and the yield and quality can beincreased. In this paper, the key aspects of pollution-free cultivation of F. cirrhosa, including habitat selection, newvariety selection, "two-stage" seedling technology, comprehensive agronomic management, wild tending mode, harvestingprocessing, etc., provides guarantee for the pollution-free production of F. cirrhosa.

国家自然科学基金委员会国家自然科学基金特别资助项目（Z 2016013）：青蒿素类化合物抗疟机理研究青蒿素类化合物抗疟机理研究，负责人：屠呦呦；中华人民共和国财政部重大新药创制（2017ZX09101002-003-001）：青蒿素及其衍生物创新药物研究，负责人：向丽。