目的 本研究在中医“治未病”思想指导下，从慢性萎缩性胃炎患者的生活习惯和行为方式、情志因素等方面入手，寻找该病的危险因素，以期对高危人群进行早期筛查和干预，降低其发病率和癌变率。方法 按照临床流行病学调查方法，收集病例912例（其中454例慢性萎缩性胃炎、458例慢性非萎缩性胃炎）进行Logistic回归分析。结果 慢性萎缩性胃炎有7个危险因素，按相对危险度排序依次是幽门螺杆菌感染史、情绪抑郁、长期饮酒、长期吸烟、年龄50岁以上、常吃高温加工食品、常吃腌制食物。结论 本研究筛选出了慢性萎缩性胃炎主要的危险因素，为高危人群对其防治提供现实依据，也为开发慢性萎缩性胃炎的早期疾病预警及辅助诊断系统提供有益借鉴和科研积累。

Objective Under the guidance of TCM “preventive treatment of disease”, this study started from the aspects of living habits, behaviors and emotional factors of patients with chronic atrophic gastritis, and sought out the risk factors of the disease in order to early screening and intervention for high-risk groups, to reduce its incidence and cancer rate.Methods According to the clinical epidemiological investigation method, 912 cases (454 cases of chronic atrophic gastritis and 458 cases of chronic non-atrophic gastritis) were collected and logistic regression analysis was performed using spss software.Results There were 7 risk factors for chronic atrophic gastritis. Sort risk factors by OR was: history of Helicobacter pylori infection, emotional depression, long-term drinking, long-term smoking, over 50 years old, eating high-temperature processed foods, and eating salted food.Conclusion This study screened out the main risk factors of chronic atrophic gastritis, provided a realistic basis for the prevention and treatment of high-risk groups, and provided useful reference and scientific research for the early warning and auxiliary diagnosis system for the development of chronic atrophic gastritis.

国家自然科学基金项目面上项目(81873236):基于复杂生物网络技术的慢性萎缩性胃炎湿热证诊断模型构建，负责人:刘国萍； 国家中医药管理局第四批全国中医(临床、基础)优秀人才项目,负责人:刘国萍； 上海市科学技术委员会健康辨识与评估重点实验室(13DZ2261000),负责人:王忆勤。