为深入分析潘敏求治疗肝积的方剂用药特点，使用中医传承辅助平台系统构建151首潘敏求治疗肝积门诊的方剂数据库，依次分析肝积的流行病学分布特点、临床症状高频分布、证候分布、四气五味、归经分布、高频用药组合、组方规律、新方配伍组合，运用“频次分析”筛选46味高频单味药（频次 ≥ 15），利用“关联规则”筛选15味高频中药配伍组合，43组核心药物组合（支持度 ≥ 30%，置信度 ≥ 90%），进而通过“无监督的熵层次聚类”（相关度 = 8，惩罚度 = 2）提取了7组新方组合。潘敏求用药以“健脾理气、化瘀软坚、清热解毒”为主，强调中医辨证论治，体现调理脏腑、补益气血、攻补兼施、病证结合的治则治法。

To deeply investigate the 151 herbal prescriptions of Pan Min-qiu in treatment of liver accumulation based on the traditional Chinese medicine inheritance support system software (TCMISS) that collecting and establishing a typical database. Four properties, five tastes, channel tropism, frequency count, Chinese herbal prescriptions rules and the new prescriptions were analyzed so as to dig out the prescription rules. There were 46 high frequency single herbs were sceened by frequency analysis with a frequency more than 15. Then 15 high high frequency herbal combinations and 43 core drug combinations with a support more than 30% and confidence more than 90%, which were sceened by association rules. Furthermore 7 new prescriptions with a relevancy equal to 8 and punishment equal to 2 that used by unsupervised hierarchical entropy clustering. It was found out that these drugs mainly had the effects of liver nourishing and soothing, soft-moist and dredging-tonifying, supporting right and dispeling evil, cooperating with the method of calming the liver and resolving hard lump according to the actual situation. It reflected the thought of treatment based on syndrome differentiation in Traditional Chinese Medicine, and embodied the treatment principles and methods of regulating viscera, tonifying qi and blood, attacking and tonifying simultaneously, and combining disease and syndrome.

湖南省科技厅重点研发计划（2016SK2033）：抗肝癌中药肝复乐的物质基础与产品二次升级研究，负责人：李顺祥；国家自然基金委员会地区科学基金项目（81960797）：基于整合药理学和方证代谢组学对肝复乐抗非酒精性肝病的药效机制研究，负责人：潘宇；中国博士后科学基金面上项目（187662）：清肝降脂壮药复方抗非酒精性脂肪肝病的系统生物学研究，负责人：潘宇。