含有马兜铃酸中药的安全性是近年国内外关注的热点话题，上海交通大学医学院公共卫生学院栾洋课题组围绕马兜铃酸致癌毒性开展了系列研究，并积极组织学术讨论，继2015年和2018年开展专题讨论会后，再次邀请本领域相关研究人员就马兜铃酸与肝癌的相关性这一科学问题，发表新研究进展、综述和各自不同的学术观点，形成本专辑，以期为中药不良反应（特别是致癌性）的风险评估及防控提供有价值的参考，以及为如何科学地传承中医药提供宝贵的思路。

The safety of aristolochic acids (AAs)-containing Chinese herbal medicine has raised concern in recent years. Dr. Luan Yang with her team, are studying on the carcinogenesis of AAs in School of Public Health, Shanghai Jiao Tong University School of Medicine. She also organized workshops on herbal safety and AAs toxicity in 2015 and 2018, respectively. The present special issue aims to present the ongoing progress in AAs carcinogenesis studies, containing research articles, reviews and insights, with contributions from the leading researchers and groups in the area of Chinese herbal medicine safety study. Together with the summary of workshops on AAs safety, this issue will provide valuable reference for risk assessment and prevention and control of adverse reactions (especially carcinogenicity) of Chinese herbal medicine, and provide valuable ideas for how to scientifically inherit traditional Chinese medicine.

国家自然科学基金委员会面上项目（8187140141）：马兜铃酸物质基础与致癌毒性研究，负责人：栾洋；上海交通大学医学院栾洋研究团队长期从事遗传毒性药物毒性研究，曾于2015年和2018年分别组织和举办上海国际中药安全性研讨会，现今在此基础上组织本期专题讨论：马兜铃酸致癌性的研究、思考与讨论。