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[摘要]
目的 利用中医传承辅助系统(Traditional Chinese medicine inheritance support system ,TCMISS),分析名中医治疗老年肺癌与中青年肺癌用药规律的异同,以期更精准的指导临床用药。方法 在中国知网、万方数据知识服务平台及中文期刊服务平台中,收集建库至2018年12月间期刊文献中名中医治疗肺癌的处方。依据标准筛选符合要求的处方,并按年龄进行分组。针对两组处方运用TCMISS进行频次统计、规则分析及新方发现,进而比较两者用药规律的异同。结果 老年肺癌涉及中药249味,中青年230味。通过关联规则分析得到规则组合老年肺癌22条,中青年47条。两年龄段肺癌患者用药共同点是补气养阴、化痰解毒。用药以寒为主,兼顾热药;以肺、脾、胃为主,兼顾五脏。不同点为老年肺癌多用甘性补虚药,中青年肺癌多用苦性泻实药。补虚方面老年患者注重补气,中青年患者气阴同补。泻实方面,中青年肺癌较老年肺癌偏重于化痰散结药使用。新方分析中,老年肺癌补阴的方式为补气养阴,中青年肺癌为补血养阴。结论 老年肺癌与中青年肺癌用药同中有异,前者治疗重在补气,后者重在补气养阴、化痰散结。
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[Abstract]
Purpose To analyze the medication rules of famous doctor of TCM in treating senile lung cancer and Young and middle-aged lung cancer by using Traditional Chinese medicine inheritance support system (TCMISS).TCMISS in order to guide clinical medication more accurately.Method To collect the literature and journals about prescription of famous doctor of TCM for lung cancer from the establishment of the database to December 2018 in CIKI, Wanfang Data, and Chinese Journal Service Platform. The prescriptions are screened according to the criteria and grouped according to age. Frequency statistics, rule analysis and new prescription discovery are conducted between the two groups used TCMISS, and then to compare the similarities and differences.Result There are 249 kinds of traditional Chinese medicines for senile lung cancer and 230 kinds for Young and middle-aged lung cancer. The results show that there are 22 rules for senile and 47 rules for Young and middle-aged by analysis of association rules. The similarity in the medication rules between two age groups is that tonifying Qi, nourishing Yin, resolving phlegm and detoxifying are commonly used drugs. Drug use mainly considers cold, supplemented by hot medicine, mainly lung, spleen and stomach, taking into account the five viscera. The difference is that most of the senile lung cancer use tonifying medicine, while Young and middle-aged lung cancer use purgative medicine. In the aspect of tonifying deficiency, the senile patients pay attention to tonifying Qi, while the Young and middle-aged patients pay attention to tonifying both Qi and Yin. The young and middle-aged patients pays more attention to the use of resolving phlegm and detoxifying than the senile patients.In the analysis of the new prescription,in the way of tonifying Yin, the senile patients is tonifying qi and Yin, while the Young and middle-aged patients is tonifying blood and Yin.Conclusion Prescriptions for two age groups have similarities and differences, with emphasis on each other, suggesting that the senile patients pay attention to tonifying Qi, while the Young and middle-aged patients pay attention to tonifying both Qi and Yin and the use of resolving phlegm and detoxifying.
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