奥沙利铂是抗肿瘤的临床常用药，具有抗癌谱广、骨髓抑制轻的优点，明显的周围神经毒性是其主要副反应，使其临床使用被局限，目前尚无有效的防治办法。在奥沙利铂神经毒性的防治上中医药有独特的优势，外治法因其安全、简便、有效的优点被广泛用于临床。中医药外治方法各异，其理论与方法各具特色，疗效显著，现将奥沙利铂相关周围神经病变的中医药外治研究进展综述如下，以期为临床防治奥沙利铂相关周围神经病变提供参考。

Oxaliplatin is an anticancer drug commonly used in clinic, which has the advantages of wide anticancer spectrum and little bone marrow inhibition. Peripheral neurotoxicity is the most common side effect of oxaliplatin, which limits its application in clinic. There is no effective prevention and treatment at present. Traditional Chinese medicine has unique advantages in the prevention and treatment of oxaliplatin-induced neurotoxicity, and the external treatment method is widely used in clinic because of its safe, simple and effective advantages. There are some ways in external treatment of TCM, their theories and methods are unique and the curative effect is remarkable. The research progress of the external treatment of oxaliplatin-induced peripheral neuropathy was summarized as follows, in order to provide references for the clinical prevention and treatment of oxaliplatin-induced peripheral neuropathy.

江苏省中医药管理局面上项目（YB2015035）：基于TRPs通道探讨当归四逆汤对奥沙利铂神经毒性作用的研究，负责人：霍介格；中央级公益性科研院所基本科研业务费专项资金资助课题（ZZ08080014）：黄芪桂枝五物配方颗粒缓解奥沙利铂相关周围神经毒性的临床评价，负责人：霍介格；江苏省卫生厅（BRA2015493）：益气温经复方中药对OXIN作用的临床研究，负责人：霍介格。