阿尔茨海默病（Alzheimer"s disease，AD）属于多因素、多机制类疾病，已对人类健康造成了严重的威胁。针灸作为传统医学的重要组成部分，具有多靶点、多途径和多层面的作用特点。本文对近年来国内外有关针灸治疗AD的研究进行了回顾，发现针灸可通过调控脑内蛋白质的异常表达、调控小胶质细胞的生理病理状态、调控线粒体自噬、调控表观遗传修饰、发挥神经元保护效应、改善突触可塑性、调控氧化应激反应和调控能量代谢等多种途径发挥对AD的整体调控效应。深入探析针灸治疗AD的效应机制，揭示其深层作用原理，以期为AD的临床诊断和治疗提供科学合理的理论依据。

Alzheimer"s disease (AD) is a multi-factor and multi-mechanism disease, which has posed a serious threat to human health. As an important part of traditional medicine, acupuncture has the characteristics of multi-target, multi-pathway and multi-layer. This paper reviews the studies on acupuncture and moxibustion in the treatment of AD in China and overseas in recent years, and finds that acupuncture can treat AD in the following ways: 1) regulating the abnormal expression of proteins in the brain; 2) regulating the physiological and pathological state of microglia; 3) regulating mitochondrial autophagy; 4) regulating epigenetic modification; 5) protecting neurons; 6) improving synaptic plasticity; 7) regulating oxidative stress response; 8) regulating energy metabolism. An in-depth analysis of the effect mechanism of acupuncture and moxibustion on AD can provide a scientific and reasonable theoretical basis for the clinical diagnosis and treatment of AD.