慢性乙型病毒性肝炎（慢乙肝）是临床常见的感染性疾病，其病程可长达20-30年。中医治疗慢乙肝有特定的优势。慢乙肝中医证候的蛋白质组学研究是了解慢乙肝不同证候及证候间的分子标签、发现生物标志物和中药作用靶点的有效途径。本文就目前蛋白质组学方法应用于慢乙肝中医证候的研究现状进行综述，介绍常见的蛋白质组学技术应用于慢乙肝不同证候，包括肝胆湿热证、肝郁脾虚证、虚证、脾胃湿热证型以及证候之间的差异蛋白质组学相关研究，旨在为慢乙肝中医证候客观化研究提供一定的生物学基础依据。

Chronic hepatitis B virus (CHB) infection is a common clinical infectious disease that can last up to 20-30 years. Traditional Chinese medicine (TCM) has specific advantages in the treatment of CHB. Proteomics study of TCM syndrome of CHB is an effective way to understand the molecular labels of different symptoms and inter-symptoms of CHB, and to discover biomarkers and targets of action of TCM. In this paper, we review the current proteomic approaches in the application of TCM syndromes of CHB. We introduced the common proteomic techniques applied to different syndromes of CHB, including liver-biliary damp-heat syndromes, liver-depressed spleen-deficiency syndromes, deficiency syndromes, spleen-stomach damp-heat syndromes, and proteomic studies on the differences between syndromes, aiming to provide some biological basis for the objective study of TCM syndromes of CHB.

国家自然科学基金委员会面上项目（81273630）：慢性乙肝证候差异蛋白组学及方药干预研究，负责人：冯培民。