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[摘要]
目的 总结藏医治疗跌打损伤外用方剂用药规律及药性研究。方法 收集《四部医典》中主治跌打损伤的外用方剂,构建藏医治疗跌打损伤外用方剂复杂网络数据集,计算网络的拓扑性质参数,分析跌打损伤外用方剂的核心药物、方药配伍规律及药性特点。结果 共筛选出符合条件的外用方剂223首,涉及药物286种,药物节点度靠前的药物有甜醅、酸奶、熊胆、鱼胆、面粉、秦艽等。常用组合药物中甜醅-面粉、甜醅-酸奶、冰片-熊胆等是藏医治疗跌打损伤的常用组合药物。药物六味分析发现,甘味与苦味占主要味道;同样三化味中甘化味与苦化味居多;药物十七效分析发现,软效、重效、钝效等排名靠前,结论 运用复杂网络方法可以发现藏医跌打损伤外用方剂的组方配伍规律,为总结和分析藏医外用药物提供更准确、更多维度的依据,进而或可有助于藏药新药开发提供思路。
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[Abstract]
Objective To summarize the regularity and properties of external prescriptions of Tibetan medicine for treatment of bruises.Methods The topical prescriptions for traumatic injuries in the “Rgyud bzhi” were collected to construct a complex network data set of the external prescriptions for traumatic injuries of Tibetan medicine, and to calculate the topological parameters of the network, and analyze the key medicines of the external prescriptions for traumatic injuries and the characteristics and rules of compound medications.Results A total of 223 qualified external prescriptions were screened and it involving 286 kinds of medicines. The medicines with the highest drug nodes were sweet glutinous rice, yogurt, bear bile, fish bile, flour, gentian, and sweet mash-flour, sweet mash-yogurt, borneol-bear bile were the most common drugs of using in compound medicines in Tibetan medicine to treat bruises. The six-flavor analysis of drugs found that sweetness and bitterness accounted for the main flavors; sweetness and bitterness are the main flavors from the “Three converted flavors”; the seventeen-effect analysis of drugs have found that the soft effect, heavy effect, and dry effect were the main effect.Conclusion The method of using complex network is able to discover the prescription compatibility of external prescriptions for traumatic injury in Tibetan medicine, and it is helpful of providing more accurate and more dimensional basis for summarizing and analyzing the externally used Tibetan medicines, which may help provide ideas for the development of new Tibetan medicines.
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