目的 研究睡眠质量在大学生阳虚体质与抑郁症状之间的中介作用，为制定中医防治抑郁的综合方案提供依据。方法 采用横断面研究的方法，随机抽取湖北、甘肃、广东中医药大学大一至大三1028名在校学生作为研究对象，采用一般资料调查表、中医阳虚体质量表、匹兹堡睡眠质量指数、抑郁自评量表进行调查。采用Spearman法进行相关性分析，应用潜变量中介效应模型分析中介效应。结果 大学生失眠的检出率为23.7%，抑郁检出率为40.9%。相关分析结果显示，大学生阳虚体质得分与SDS得分（r = 0.23，P < 0.01）、PSQI得分与SDS得分（r = 0.40，P < 0.01）、阳虚体质得分与PSQI得分（r = 0.36，P < 0.01）呈正相关关系，有统计学意义。在阳虚体质与抑郁相关的潜变量中介效应模型中，睡眠质量中介效应值为0.21。结论 大学生睡眠质量欠佳在阳虚体质与抑郁之间起中介作用。

Objective To study the mediating effect of yang-deficiency constitution between sleep quality and depression in medical students, and to provide a basis for the comprehensive prevention and treatment.Methods Totally 1028 students were selected from Hubei, Gansu and Guangdong universities of Chinese medicine by using the method of cross - sectional study. The general information questionnaire, the TCM constitution scale, Pittsburgh Sleep Quality Index Scale (PSQI) and Self-rating Depression Scale were used to assess constitution, sleep quality and depression. Spearman method was used for correlation analysis and latent variable mediating effect model was used to analyze the mediating effect.Results The detection rate of insomnia and depression was 23.7% and 40.9% respectively. Correlation analysis results showed that SDS score was also positively correlated with yang-deficiency constitution transformation score (r = 0.23, P < 0.01), the total PSQI score was positively correlated with SDS score (r = 0.40, P < 0.01) and yang-deficiency constitution conversion score (r = 0.36, P < 0.01). The correlation was statistically significant. In the mediating effect model of sleep quality and depression, the mediating effect value of sleep quality was 0.21.Conclusion The poor sleep quality mediates the association between yang-deficiency constitution and depression in college students.

中华人民共和国科学技术部国家重点研发计划（2018YFC1705600）：慢性失眠中医诊疗新方案及机制研究，负责人：王平。