慢性疼痛是困扰全人类的难题之一，由于其发病机制尚不完全清楚，导致其并未得到完全有效的控制。针刺治疗在世界范围内已成为治疗慢性疼痛的主要疗法之一，但其作用机制仍不清晰。表观遗传学主要研究在基因核苷酸序列不发生改变的情况下，表型或基因表达发生变化，其与慢性疼痛的发生、发展密切相关。本文以表观遗传学为主要研究方向，在分子层面对其在慢性疼痛的发生、发展中的机制进行综述，并探讨表观遗传学视角下针刺的镇痛机制，以期为针刺镇痛的机制研究提供一个新的视角。

Chronic pain is one of the challenges that afflicts all of humanity, and its pathogenesis is not fully understood, resulting in its incomplete and ineffective control. Acupuncture treatment has become one of the main therapies for the treatment of chronic pain worldwide, but its mechanism of action remains unclear. Epigenetics focuses on the phenotypic or gene expression changes that occur in the absence of changes in the nucleotide sequence of genes, which are closely related to the occurrence and development of chronic pain. In this paper, epigenetics is the main research direction, and its mechanism in the occurrence and development of chronic pain is reviewed at the molecular level, and the analgesic mechanism of acupuncture from an epigenetic perspective is explored, in order to provide a new perspective for the study of the mechanism of acupuncture analgesia.

R245

国家自然科学基金委员会重大项目（81590950）：穴位的敏化研究，负责人：梁繁荣。