目的 构建个性化知识图谱技术和定性访谈法结合，进一步挖掘张忠德教授辨治间质性肺疾病临证特征与用药规律。方法 采用回顾性分析，系统收集张忠德教授广东省中医院门诊2010年8月至2020年8月治疗间质性肺疾病病历，按照诊断标准、纳入标准、排除标准，严格筛选后，通过广东省中医院大数据挖掘团队中医药大数据智能处理与知识服务系统进行数据挖掘分析，并通过多元化视觉定性访谈法，将定量与定性分析有效结合。结果 共筛选出347首方，共141味药物，常用药物频次 ≥ 84次的药物有10味，其中党参、麦芽、黄芪、紫菀、白术等为核心用药，通过症状与药物推理知识地图显示，党参、炒麦芽、黄芪、大枣、太子参、山萸肉、巴戟天等为主要治疗用药；临证遣方用药知识关联分析，得知咳嗽、耳鸣、心悸、水肿、头痛、胸闷、恶寒等为多见，针对咳嗽，首选紫苏子、橘红、桂枝等温肺降气通阳之品等；频繁聚集显示，常用药对炒麦芽-炒白术、黄芪-党参、黄精-菟丝子、前胡-紫菀、炙枇杷叶-浙贝母等；聚类分析结果得到4组关系密切的聚类新药物组合；以脾为中轴，肺肾共扶为主的“平调五脏论”，分期阶梯辨治间质性肺疾病。结论 张忠德教授认为间质性肺疾病，虚实夹杂为多见，应从肺、脾、肾着手，采用平调五脏论分期阶梯辨治，用药配伍精简，以和为贵，以平为期。

Objective To further explore the clinical characteristics and prescription patterns of Professor Zhang Zhongde''s treatment of interstitial lung disease based on the combination of personalized knowledge mapping and qualitative interview.Methods Retrospective analysis was used to systematically collect medical records of interstitial lung diseases treated from August 2010 to August 2020 in the outpatient clinic of Guangdong Provincial Hospital of Traditional Chinese Medicine by Professor Zhongde Zhang, and after strict screening according to diagnostic criteria, inclusion criteria, and exclusion criteria, data mining analysis was conducted through the Big Data Mining Team of Guangdong Provincial Hospital of Traditional Chinese Medicine Big Data Intelligent Processing and Knowledge Service System, and the diversified visual qualitative interview method was used to quantitative and qualitative analysis were effectively combined.Results A total of 347 formulas with 141 medicinals were screened, and there were 10 medicinals with the frequency of commonly used medicinals ≥ 84 times, among which Radix Codonopsis, fried Fructus Hordei Germinatus, Astragalus, Asteraceae and Atractylodes were the core medicinals, and the knowledge map of symptom and medicinal reasoning showed that Radix Codonopsis, fried Fructus Hordei Germinatus, Radix Astragali seu Hedysari, ructus Jujubae, prunus, Radix Pseudostellariae and Bacopa monniera were the main therapeutic medicinals; The analysis of the association between the knowledge of clinical prescriptions and drugs showed that cough, tinnitus, palpitation, edema, headache, chest tightness, and coldness were commonly seen, and for cough, products that warm the lung and lower the qi and promote yang, such as Perilla frutescens, xocarpium Citri Rubrum and Ramulus Cinnamomi were preferred; frequent clustering showed that the commonly used drugs were fried Fructus Hordei Germinatus - fried Rhizoma Atractylodis Macrocephalae, Radix Astragali seu Hedysari - Radix Codonopsis, Rhizoma Polygonati - Semen Cuscutae, Radix Peucedani - Radix Asteris and roasted Folium Eriobotryae - Bulbus Fritillariae Thunbergii, etc.; the clustering analysis resulted in four groups of closely related clustered new drug combinations; the treatment of interstitial lung disease was based on the “theory of harmonizing the five organs” with the spleen as the central axis and the lung and kidney as the main support, and the treatment of interstitial lung disease was identified in stages and steps.Conclusion Professor Zhang Zhongde believes that interstitial lung disease, mixed with deficiency and sufficiency, should be treated from the lungs, spleen and kidneys, using the theory of harmonizing the five organs in a step-by-step approach, and using a concise combination of medicinals, and taking a peaceful period as the most important.

R256.1