表观遗传学是生命科学领域后基因时代的研究热点，应用表观遗传修饰研究方法是男性不育症发病机制研究的前沿领域，亦是探索中医药治疗男性不育症靶点并阐释其作用机制的新途径。目前，男性不育症的病因病机尚未完全明确，现代医学尚无较好疗法，而中医药治疗男性不育症具有独特的优势和广阔的前景。新近研究发现，中医药能参与调控异常表观遗传修饰而治疗男性不育症。本文主要从男性不育症中医理论的表观遗传学基础以及从DNA甲基化、组蛋白修饰和非编码RNA三个方面在男性不育症治疗及中医药研究中的应用入手，多学科交叉，评述中医药治疗男性不育症的表观遗传作用，以期为中医药治疗该病提供新的科学依据和新思路。

Epigenetics is a research hotspot in the post-gene era in the field of life science, and the application of epigenetic modification is a frontier field in the pathogenesis research of male infertility. It is also a new way to explore the target of traditional Chinese medicine in the treatment of male infertility and explain its mechanism. At present, the etiology and pathogenesis of male infertility is not completely clear, and the treatment effect of western medicine on the disease is not good, while traditional Chinese medicine has unique advantages and broad prospects for the treatment of male infertility. Recent studies have found that traditional Chinese medicine can be involved in the regulation of abnormal epigenetic modification to treat male infertility. This paper discussed the epigenetic action of traditional Chinese medicine in the treatment of male infertility, mainly from the epigenetic basis of Chinese medicine theory of male infertility and the application of DNA methylation, histone modification and non-coding RNA in the treatment of male infertility and the research of traditional Chinese medicine, in order to provide new scientific basis and new ideas for the treatment of male infertility with traditional Chinese medicine.

国家自然科学基金委员会面上项目（81974573）：基于lncRNA TCONS_00092730调控MEI4基因探讨益肾通络方修复精子DNA损伤机制，负责人：孙自学；河南省卫健委/河南省中医管理局重大专项课题（2022ZYZD9）：益肾通络方治疗肾虚络阻型少弱精子症不育患者的临床疗效评价及基于代谢组学的机制研究，负责人：孙自学；河南省卫生健康委员会重点项目（ZYMY201809）：河南省“中原千人计划”中原名医项目，负责人：孙自学。（最多挂靠3个基金，请删减）