目的 探讨冠心病的穴位敏化现象及规律，以期为临床诊治和未来研究提供一定思路。方法 电子检索（包括中文数据库CNKI、CBM、WanFang Database、VIP和英文数据库PubMed）结合手工检索，收集冠心病穴位敏化的相关文献，运用文献计量学及数据挖掘方法整理、总结冠心病的穴位敏化现象和规律。结果 共纳入相关文献69篇，冠心病涉及的穴位敏化现象包括热敏、力敏、光敏、形敏、电敏、痛敏及少量的其它敏化形式，穴位敏化的检测手段丰富，不同敏化现象常相伴出现，其中以力敏和形敏同时出现的概率最高；冠心病常见敏化穴为内关、心俞、神门、膻中等，其中内关的敏化表现形式最为丰富，并常与膻中同时出现敏化现象；阴经的敏化发生率明显多于阳经；敏化现象多集中在手厥阴心包经、足太阳膀胱经和手少阴心经；敏化部位多集中在上肢部、胸部和背部；敏化穴位多为特定穴，其中又以络穴发生敏化现象的频次最高。结论 冠心病存在明显的穴位敏化现象，其敏化表现形式正在不断被丰富，多种敏化现象常相伴出现；敏化现象涉及的穴位、经脉及部位较为广泛，其中的高频敏化穴区部位与目前临床治疗所选穴区部位基本一致。未来应进一步明确穴位敏化动态变化规律及建立敏化标准，以期更好地辅助临床诊治。

Objective To explore the phenomenon and pattern of acupoints sensitization of coronary heart disease (CHD), and to provide some ideas for clinical diagnosis, treatment and future researches.Methods Electronic searches (including Chinese databases CNKI, CBM, WanFang Database, VIP and English database PubMed) were combined with manual searches to collect relevant literature on acupoint sensitization in CHD, and bibliometric and data mining methods were used to organize and summarize the phenomena and patterns of acupoint sensitization in coronary heart disease.Results A total of 69 related literatures were included. The sensitization phenomena included thermo-sensitization, force-sensitization, light-sensitization, morphological-sensitization, electrical-sensitization, pain-sensitization and a small amount of other sensitization. The detection means of sensitization phenomenon were abundant. Different sensitization phenomena often appeared together, among which the probability of force-sensitization and morphological-sensitization was the highest. The common sensitization points of CHD were Neiguan (PC6), Xinshu (BL15), Shenmen (TF4), Danzhong (RN17), and etc. The sensitization of Neiguan was the most abundant, and the sensitivity of Danzhong and Neiguan often occurred simultaneously. The incidence of the sensitization of the Yin meridian was significantly higher than that of the Yang meridian. The sensitization mostly focused on the pericardium meridian of hand-jueyin, the bladder meridian of foot-taiyang and the heart meridian of hand-shaoyin. The sensitized parts were mostly in the upper limbs, chest and back. The sensitization acupoints were mostly specific acupoints, and the sensitization frequency of Luo-connecting points was the highest.Conclusion CHD had obvious acupoints sensitization phenomenon, and its sensitization forms were being enriched constantly. Multiple sensitization phenomena often occurred together. The sensitization of CHD involved a wide range of acupoints, meridians and areas, among which of the high-frequency sensitizations were basically consistent with the selected acupoints, meridians and areas of the current clinical treatment. In the future, the dynamic changes of acupoints sensitization should be further clarified and the sensitization standard should be established to better assist the clinical diagnosis and treatment.

R245.9

国家自然科学基金委员会重大项目（81590950）：穴位的敏化研究，负责人：梁繁荣。