[关键词]
[摘要]
扩张型心肌病(Dilated cardiomyopathy,DCM)临床表现为进行性心力衰竭,“能量饥饿”学说认为心脏衰竭的原因与心肌能量供需失衡有关,为心脏提供额外能量以缓解心脏“饥饿”状态成为优化心肌能量代谢治疗的新靶点。气虚血瘀与“能量饥饿”关系密切,益气升陷活血类中药多靶点、多途径调节心肌能量代谢,为心肌细胞提供更多能量物质,缓解心脏的“饥饿”状态,缓解心力衰竭进程。本文总结近几年益气升陷活血中药治疗DCM“能量饥饿”状态的研究,从“能量饥饿”学说探讨DCM气虚血瘀治疗的最新进展,为优化DCM心肌能量代谢治疗提供新思路。
[Key word]
[Abstract]
Dilated cardiomyopathy (DCM) is characterized by progressive heart failure. The theory of "energy hunger" believes that the cause of heart failure is related to the imbalance of myocardial energy supply and demand. Providing additional energy for the heart to alleviate the "hunger" state of the heart has become a new target for optimizing the treatment of myocardial energy metabolism. Qi deficiency and blood stasis are closely related to "energy starvation". Yiqi Shengxian Huoxue Chinese medicine regulates myocardial energy metabolism by multiple targets and pathways, provides more energy substances for myocardial cells, alleviates the "hunger" state of the heart and alleviates the process of heart failure. In this paper, the author summarized the research on the treatment of "energy starvation" in DCM with Yiqi Shengxian Huoxue Chinese medicine in recent years, discussed the latest progress in the treatment of DCM with qi deficiency and blood stasis from the "energy hunger" theory, so as to provide new ideas for optimizing the treatment of DCM with myocardial energy metabolism.
[中图分类号]
[基金项目]
国家自然科学基金委员会面上项目(81573920):基于内质网应激及时相性变化研究抗纤益心方抑制扩张型心肌病大鼠心肌细胞凋亡的机制,负责人:王振涛;河南省卫生健康委员会河南省中医药科学研究重大专项(2018ZYZD11):基于真实世界扩张型心肌病慢性稳定期中医治疗方案研究,负责人:王振涛。