糖尿病相关性肌少症是目前糖尿病领域研究热点，肌少症是2型糖尿病的独立危险因素，引起多种不良事件，增加糖尿病患者再住院率及死亡率，2型糖尿病又反过来加重肌少症病情，二者相互影响，恶性循环，现代研究对肌少症与糖尿病之间的关系尚无确切认识。我们从中医理论出发，认为其病理发展经过“脾虚不运，四肢肌肉失养”、“郁热内生，热盛肉削”、“痰浊瘀滞，肌肉不用”3个阶段，总的病机演变概括为虚-热-瘀3个重点，但无论病理演变阶段如何，“脾不散精”都是糖尿病相关肌少症发生发展的基本所在，提示临床治疗方面应从恢复脾气散精功能入手，注重健脾助运，以恢复精微布散为首要，为糖尿病相关性肌少症的防治提供科研和临床干预思路。

Diabetes-associated sarcopenia is currently a hot topic in the field of diabetes research. Sarcopenia is an independent risk factor for type Ⅱ diabetes mellitus, which causes many adverse events and increases the rate of rehospitalization and mortality in diabetic patients. Type Ⅱ diabetes mellitus, in turn, aggravates sarcopenia, and the two affect each other in a vicious circle. The relationship between sarcopenia and diabetes mellitus has not yet been clearly understood in modern research. From the theory of Chinese medicine, we believe that the pathological development of sarcopenia goes through three stages: "spleen deficiency, muscle weakness," "internal fever, muscles wasting," "phlegm and abdominal distension, muscle damaging." The overall pathological evolution is summarized as weakness-fever-bruising. However, regardless of the stage of pathological evolution, "spleen weakness" is the basic cause of the development of diabetes-related sarcopenia. This suggests that clinical treatment should start from restoring the spleen's function of energy transportation, focusing on spleen health, and restoring weakness and motility as the first priority, providing scientific research and clinical intervention ideas for prevention and treatment of diabetes-related sarcopenia.

国家自然科学基金青年基金项目（8200153442）：益气养阴活血法在糖尿病血糖维稳中对胰岛α-β环路交互作用的影响研究，负责人：谢红艳；四川省科技厅国际创新合作/港澳台科技创新合作项目（2020YFH0165）：从线粒体功能探讨“脾气散精”环节对糖尿病大鼠骨骼肌保护作用的机制研究，负责人：高泓；四川中医药文化协同发展研究中心文化协同项目（2020WH051）：以阴阳五行理论为基础的中医药与太极文化关系研究，负责人：高泓，