目的 总结亚健康与中医体质类型相关性研究及现状，探讨亚健康的中医体质分布规律，为亚健康的中医药养生保健提供循证医学证据，为传统中医功能声称的保健食品功能研究提供方向。方法 计算机检索中国知网（CNKI）、万方数据（WANFANG DATA）、重庆维普（CQVIP）、PubMed及EMBASE数据库，纳入所有评价亚健康与中医体质类型相关性的临床研究文献。采用R version 4.0.4软件进行单率Meta分析、OR值（odds ratio）及其95% CI （confidence interval）表达效应值。结果 共纳入31项研究，研究总样本量为55 059例，其中亚健康人群43 707例，一般人群11 352例。平和质、气虚质、阳虚质、气郁质为亚健康人群占比前四的体质，比例分别为21.4%（95% CI：16.2-27.2%）、21.2%（95% CI：18.0-24.4%）、16.2%（95% CI：13.7-18.7%）、13.5%（95% CI：11.2-16.2%）。对亚健康人群及一般人群进行比较，发现气郁质、气虚质、阳虚质、平和质发生亚健康风险的OR值分别为4.97（95% CI：3.03-8.15）、3.99（95% CI：2.17-7.31）、2.30（95% CI：1.52-3.48）、0.15（95% CI：0.10-0.24），差异均具有统计学意义，表明偏颇体质是发生亚健康的风险因素，而平和质是发生亚健康的保护因素。从性别来看，亚健康男性和女性的气虚质、痰湿质、湿热质的比例相当，而女性的阳虚质、阴虚质、气郁质、血瘀质的比例要高于男性。纳入研究的方法学质量整体偏低，漏斗图分析显示存在发表偏倚风险。结论 气郁质、气虚质、阳虚质是亚健康人群的主要偏颇体质类型，也是发生亚健康的风险因素。建议今后研究进一步探讨3大偏颇体质与亚健康的关联性，为亚健康的中医药养生保健提供有价值的参考。

Objective To study the distribution rule of TCM constitution and sub-health based on the current studies of the correlation between TCM constitution and sub-health, to provide proof of evidence-based medicine evidence for TCM health care of sub-health, and to provide direction for the research of TCM health function.Methods The computer searched the CNKI, WANFANG DATA, CQVIP, PubMed and EMBASE, collected the clinical research literatures on the correlation between sub-health and TCM constitution, and conducted a meta-analysis to systematically review the documents that met the inclusion criteria and preliminary demonstrated the clinical efficacy of moxibustion in the treatment of depression. Single rate meta-analysis, odds ratio (OR) and 95% confidence interval (CI) were performed by R version 4.0.4 software.Results A total of 31 studies were included, with a total sample size of 55059 cases, including 43707 cases of sub-health population and 11352 cases of general population. The constitution of gentleness type, qi-deficiency type, yang-deficiency and qi-depression type accounted for 21.4% (95% CI: 16.2-27.2%), 21.2% (95% CI: 18.0-24.4%), 16.2% (95% CI: 13.7-18.7%) and 13.5% (95% CI: 11.2-16.2%) respectively. The OR of constitution of qi-depression type, qi-deficiency type, yang-deficiency type, and gentleness type were 4.97 (95% CI: 3.03-8.15), 3.99 (95% CI: 2.17-7.31), 2.30 (95% CI: 1.52-3.48) and 0.15 (95% CI: 0.10-0.24), respectively, which indicating that biased constitution was the risk factor of sub-health, gentleness type constitution was the protective factor of sub-health. There was no gender difference on the proportion of the constitution of phlegm-dampness type, qi-deficiency type, phlegm-dampness type and damp-heat type, while the proportion of yang deficiency, yin deficiency, qi-depression and blood-stasis type in female was higher than male. The methodological quality of the included studies was generally low, and funnel plot analysis showed that there was a risk of publication bias.Conclusion The constitution of qi-depression type, qi-deficiency type and yang-deficiency type were the main types of sub-health population, which were also the risk factors of sub-health. We suggested that future studies should further explore the relationship between the three biased constitutions and sub-health, so as to provide valuable reference for the health care of sub-health by traditional Chinese medicine.

R2-03