[关键词]
[摘要]
目的 运用数据挖掘方法分析黄力教授治疗慢性心力衰竭的用药规律。方法 收集2016年1月1日-2021年1月1日中日友好医院黄力教授门诊处方数据,进行整理和筛选,应用频数分析、关联规则分析及聚类分析方法对黄力教授治疗慢性心力衰竭的处方进行挖掘与整理。结果 共收集黄力教授治疗慢性心力衰竭处方91例,涉及中药178味,累计用药频次1 602次。处方中药物的药性以温、平为主;药味以甘、辛、苦为主;归经以肺、脾、心、胃经为主;药物功效以补中益气、健脾宁心、润肠通便、敛阴止汗为主。关联规则分析总结出用药核心配伍组合为“黄芪-白术-茯苓-川芎-葛根”。聚类分析显示高频药物可分为4类:健脾益气类;活血化瘀类;利水消肿类;升阳解表类。结论 黄力教授治疗慢性心力衰竭多以补中益气汤中核心药对为底方进行画裁,从调整“气、血、水”三者关系入手,灵活运用补益中气、活血化瘀、温阳利水三法,临床疗效颇佳。
[Key word]
[Abstract]
Objective To analyze the medication rule of Professor Huang Li in the treatment of chronic heart failure (CHF) by data mining.Methods The prescription data of Professor Huang Li in China-Japan Friendship Hospital from January 1, 2016 to January 1, 2021 were collected and screened. The prescriptions of Professor Huang Li in the treatment of chronic heart failure were excavated and sorted out by means of frequency analysis, association rule analysis and cluster analysis.Results A total of 91 prescriptions of chronic heart failure treated by Professor Huang Li were collected, involving 178 kinds of traditional Chinese medicine, and the drug was used for a total of 1602 times. In the prescription, the medicine is mainly warm and flat; the taste is sweet, pungent and bitter; meridians are mainly lung, spleen, heart and stomach meridians; and the drug efficacy is mainly tonifying qi, invigorating spleen and calming heart, moistening intestines and relieving bowels, collecting yin and stopping perspiration. According to the analysis of association rules, the core compatibility combination is "Astragalus-Atractylodes macrocephala-Poria cocos-Ligusticum chuanxiong-Pueraria". Cluster analysis shows that high-frequency drugs can be divided into four categories: invigorating spleen and tonifying qi, activating blood circulation and removing blood stasis, promoting diuresis and detumescence, promoting yang and relieving surface.Conclusion Professor Huang Li usually uses the core medicine pair in Buzhong Yiqi decoction as the base prescription in the treatment of chronic heart failure, starting with adjusting the relationship among "qi, blood and water", and flexibly using the three methods of tonifying middle qi, activating blood circulation and removing blood stasis, warming yang and promoting diuresis. The clinical effect is quite good.
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[基金项目]
国家科学技术部国家重点研发计划项目(2017YFC1700102):心衰气虚证的辩证标准研究,负责人:王伟。