目的 基于临床信息系统分析总结真实世界的数据，采用数据挖掘的方法探讨中医药治疗糖尿病肾病的用药规律。方法 收集2018年1月-2020年12月上海中医药大学附属曙光医院宝山分院健康信息系统确诊的糖尿病肾病的门诊或住院患者的诊疗信息，建立Excel数据库，采用Excel 2010软件统计高频药物的四气、五味、归经及功效；使用SPSS Modeler 18.0软件中的Apriori算法分析关联规则，采用web节点建构药对关联网状图；运用SPSS 25统计软件进行因子分析。结果 本研究最终纳入477例接受中药饮片治疗的DKD患者，在1203条方剂信息中，涉及中药462种；使用频数排名前5位的中药分别是黄芪、黄精、石斛、山茱萸、麦冬；使用频数前5类的中药类别分别是补气药、补阴药、清热燥湿药、活血调经药、息风止痉药；在30味高频药物中，苦、甘、辛药味最为常见；药性寒、温数量接近；归脾经、肝经、肺经、肾经居多；关联规则提示，药物组合中置信度最高的组合为地龙-当归-僵蚕，因子分析共得到5个有效因子，累积贡献率为47.33%。结论 中医药治疗DKD在补益气血阴阳的同时，兼顾对瘀血、湿邪和痰饮的治疗，结合证型，可考虑使用黄芪、黄精、石斛、山茱萸、麦冬、金蝉花等药物的使用，清热燥湿药物如黄连、黄芩、黄柏可适当加入，为使邪有去处，大黄、车前子或可增添疗效。

Objective To summarize and sort out real-world data based on the clinical information system, and use data mining methods to explore the rules of traditional Chinese medicine in the treatment of DKD.Methods The diagnosis and treatment information of outpatients or inpatients of DKD of HIS in Baoshan Branch of Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2018 to December 2020 was collected, and an Excel database was established. Perform descriptive statistics on Qi, Wuwei, Meridian and Efficacy; use Apriori algorithm in SPSS Modeler 18.0 software to analyze association rules, and use web nodes to construct a drug-pair association network diagram; use SPSS 25 statistical software to perform factor analysis.Results This study finally included 477 patients with DKD who were treated with decoction pieces of traditional Chinese medicine. Among the 1203 prescriptions information, 462 types of Chinese medicines were involved; the top 5 Chinese medicines used in frequency were Astragalus, Polygonatum, Dendrobium, Dogwood, and Ophiopogon; frequency of use The first five types of Chinese medicines are qi-tonifying drugs, yin-tonifying drugs, heat-clearing and damp-drying drugs, blood-stimulating menstrual-regulating drugs, and anti-wind and antispasmodic drugs; among the 30 high-frequency drugs, bitter, sweet, and pungent are the most common; the drugs are cold in nature. The number of spleen meridians, liver meridians, lung meridians and kidney meridians are mostly; the association rules suggest that the highest confidence are earthworm-angelica-stiff; factor analysis yielded a total of 5 effective factors, with a cumulative contribution rate of 47.33%.Conclusion TCM treatment of DKD can not only replenish qi, blood, yin and yang, but also treat blood stasis, dampness, and phlegm. Combining syndrome types, drugs such as Astragalus, Polygonatum, Dendrobium, Dogwood, Ophiopogon, Jinchanhua, etc. can be considered When used, heat-clearing and dampening medicines such as Coptis chinensis, Scutellaria baicalensis Georgi, and Phellodendron amurense can be added appropriately, and rhubarb and Psyllium may increase the curative effect.

国家自然科学基金委员会青年项目（82004117）：黄芪甲苷通过抑制miR-216a-5p/Beclin1促进内皮细胞自噬抗糖尿病动脉粥样硬化的作用及机制研究，负责人：李园园；上海市卫生健康委员会科研课题青年项目（20214Y0195）：糖肾地黄汤治疗肾阴虚型糖尿病肾病的临床疗效观察及对肠道菌群的作用机制，负责人：杨超茅；宝山区科学技术委员会科技创新专项资金医学卫生项目青年项目（20-E-14）：基于ACE/AngⅡ/AT1R轴探讨糖肾地黄汤治疗早期糖尿病肾病的作用机制，负责人：杨超茅。