本文介绍了孙伟教授诊治慢性肾病的学术思想及经验总结。慢性肾脏病属中医学的“腰痛”“关格”“虚劳”等范畴，发病主要与脾肾关系密切。慢性肾脏病若发展至终末期阶段，都要进行肾脏替代治疗。孙伟教授认为肾虚湿瘀是慢性肾脏病基本病机，并应用“湿热伤肾”理论系统阐释了该病的诊治方案。认为湿热是本病进展的启动因子，肾元亏虚为发病之本，瘀毒是湿热伤肾的病理结局，明确了湿热证的诊断要点，确立了益肾清利活络治疗原则，从而延缓肾功能进展。

This paper introduces professor Sun Wei's academic thought and experience in diagnosis and treatment of chronic kidney disease. Chronic kidney disease belongs to the category of "lumbago", "guange" and "fatigue" in Traditional Chinese medicine, and the incidence is mainly closely related to the spleen and kidney. If chronic kidney disease develops to the terminal stage, kidney replacement therapy should be carried out. Professor Sun Wei believes that kidney deficiency and dampness stasis is the basic pathogenesis of chronic kidney disease, and systematically explains the diagnosis and treatment of the disease with the theory of "dampness and heat injury to the kidney". It is concluded that damp-heat is the initiating factor of the progression of the disease, nephron deficiency is the origin of the disease, and blood stasis and toxin is the pathological outcome of damp-heat injury to the kidney.

国家科学技术部国家“十三五”支撑计划项目（2019YFC1709903）：心脑血管疾病等慢病中医健康状态监测、预警与防控模式的示范研究；负责人：段姝伟；江苏省中医药管理局江苏省名老中医药专家孙伟传承工作室项目(苏中医教科【2019】10号)，负责人:陈继红；吉林省科学技术厅科技发展计划项目（20210101201C）：基于TGF-β1/Smd3及自噬作用研究补肾健脾、化瘀利水法治疗糖尿病肾病的作用机制，负责人:崔成姬。