[关键词]
[摘要]
再生障碍性贫血是一种罕见的危及生命的骨髓衰竭,发病率呈上升趋势,且趋于年轻化。中药防治虚劳、血证具有悠久的历史,其治疗再生障碍性贫血涉及多组分、多靶点、多通路的协同调控作用。文章从造血干/祖细胞、免疫系统、骨髓微环境异常三个方面分类阐述中药复方及成分对再生障碍性贫血的治疗作用及相关因子表达,并对中药复方中常用药物频次及归经分析,发现补虚药在再生障碍性贫血治疗中使用频次最高,与其以虚为主的病症相符合,并发现与之相关脏器为肝、脾、肾。综述再生障碍性贫血的发生机理及中药对其的预防及治疗作用,对后续有针对性地开展中药改善再生障碍性贫血的研究具有重要意义。
[Key word]
[Abstract]
Aplastic anemia is a rare and life-threatening bone marrow failure that is becoming more common and tends to affect younger individuals. Traditional Chinese medicine has a long history of preventing and treating asthenia and blood syndrome. Its treatment of aplastic anemia involves coordinated regulation through multiple components, targets, and channels. The article classifies and elaborates on the therapeutic effects of traditional Chinese medicine compounds and their components on aplastic anemia. As well as the expression of related factors from three aspects: hematopoietic stem/progenitor cells, the immune system, and bone marrow microenvironmental abnormalities. It also analyzes the frequency and meridian of commonly used drugs in traditional Chinese medicine compounds. Deficiency tonifying drugs were found to be the most frequently used treatment for aplastic anemia, which is consistent with the deficiency-based nature of the disease. The related organs affected are the liver, spleen, and kidney. This paper reviews the mechanism of aplastic anemia and the preventive and therapeutic effects of traditional Chinese medicine. The study is of great significance for the follow-up research on traditional Chinese medicine in improving aplastic anemia.
[中图分类号]
[基金项目]
广西中药药效研究重点实验室运行补助项目(20-065-38);广西中医药大学“桂派中医药传承创新团队”项目(2022A005);国家药品监督管理局中药材质量监测与评价重点实验室开放课题基金