[关键词]
[摘要]
脑老化过速已成为亟待解决的社会问题和医学难题,其中遗忘型轻度认知功能障碍(Amnesia mild cognitive impairment,aMCI)因更易进展为阿尔茨海默病(Alzheimer's disease,AD)痴呆而备受关注。国内外多项研究报道,执行功能衰退是认知老化的始动因子、关键损伤和敏感指标,且长期负性情绪积累肝失疏泄是罹患aMCI的重要危险因素,疏肝法可改善aMCI患者总体认知功能,但以上机制均有待进一步研究阐释。本文聚焦认知衰退早期敏感成分和执行功能核心成分之一的认知灵活性水平,总结梳理aMCI的发病机制、危险因素、敏感指标及认知神经科学研究事件相关电位和眼动技术,并重点探讨长期负性情绪积累肝失疏泄对aMCI和认知灵活性的影响及研究进展,以期为aMCI患者的情志病机干预和治疗提供参考和借鉴,为中医药防治认知功能衰退过速类疾病提供新视角、方法和思路。
[Key word]
[Abstract]
Rapid brain aging has become a social and medical problem to be solved urgently, among which amnesia mild cognitive impairment (aMCI) has attracted much attention because it is more likely to develop into Alzheimer's disease (AD) dementia. Many studies at home and abroad have reported that executive function decline is the initiating factor, key damage and sensitive index of cognitive aging, and long-term negative emotional accumulation and liver failing to facilitate the coursing of Qi is an important risk factor for aMCI. Soothing liver-qi stagnation therapy can improve the overall cognitive function of aMCI patients, but the above mechanisms need to be further studied and explained. This paper focuses on the cognitive flexibility level of early sensitive components of cognitive decline and one of the core components of executive function, and summarizes the pathogenesis, risk factors, sensitive indicators, event-related potentials and eye tracking techniques of aMCI, and focuses on the effects and research progress of long-term negative emotional accumulation and liver failing to facilitate the coursing of Qi on aMCI and cognitive flexibility. The purpose of this study is to provide reference and reference for the intervention and treatment of emotional pathogenesis in patients with aMCI, and to provide new perspectives, methods and ideas for the prevention and treatment of diseases with excessive cognitive decline in traditional Chinese medicine.
[中图分类号]
[基金项目]
国家自然科学基金委员会面上项目(81873208);河南省“双一流”创建学科中医学科学研究专项(HSRP-DFCTCM-2023-1-02);河南省自然科学基金面上项目(242300420106)