[关键词]
[摘要]
结直肠癌(Colorectal cancer,CRC)是一种在结肠或直肠内形成的恶性肿瘤,通常是由正常细胞在体内发生不受控制的生长和分裂所引起的。细胞凋亡(cell apoptosis)、焦亡(pyroptosis)和坏死性凋亡(necroptosis)是结直肠癌中关键的细胞死亡途径。综合治疗策略包括细胞死亡诱导剂与化疗、免疫治疗以及靶向治疗的协同作用。中药作为辅助治疗手段在调节细胞死亡过程中发挥重要作用,中西医联合治疗在癌前病变、提高疗效、减少不良反应以及降低耐药性方面展现出显著效果。尽管细胞死亡机制的研究尚不充分,但强调中医药的独特特色,明确中药抗肿瘤机制,实现中西医结合治疗结直肠癌的现代科学国际化成为未来的研究方向。本文将从中西医结合的角度全面综述细胞凋亡、焦亡和坏死性凋亡的分子机制,以及在结直肠癌治疗中的调控作用。
[Key word]
[Abstract]
Colorectal cancer, CRC is a malignant tumor formed in the colon or rectum, usually caused by uncontrolled growth and division of normal cells in the body. Cell apoptosis, pyroptosis, and necroptosis are key pathways of cell death in colorectal cancer. The comprehensive treatment strategy includes the synergistic effect of cell death inducers with chemotherapy, immunotherapy, and targeted therapy. Traditional Chinese medicine plays an important role as an adjuvant therapy in regulating cell death. The combination of traditional Chinese and Western medicine has shown significant effects in precancerous lesions, improving efficacy, reducing adverse reactions, and reducing drug resistance. Although the research on the mechanism of cell death is not yet sufficient, emphasizing the unique characteristics of traditional Chinese medicine, clarifying the anti-tumor mechanism of traditional Chinese medicine, and achieving modern scientific internationalization of integrated traditional Chinese and Western medicine treatment for colorectal cancer have become future research directions. This article will comprehensively review the molecular mechanisms of cell apoptosis, pyroptosis, and necroptosis from the perspective of combining traditional Chinese and Western medicine, as well as their regulatory role in the treatment of colorectal cancer.
[中图分类号]
[基金项目]
湖北陈孝平科技发展基金会(AF/SC-08/03.2)湖北陈孝平科技发展基金会2023年度肿肿瘤防治研究槐耳专项基金,负责人:张楠。[第一作者]喻士平,在读硕士,从事应用中医药或联合西药在普外疾病方面的临床与实验研究,Email:19937869642@163.com[通讯作者]张楠,博士,主任医师,教授,主要研究方向:外科相关疾病临床与实验研究,Email:jinglei.1999@163.com ,张楠2**,孙唯义2,郅强2,沙俊生1,陈舒1,高楠1