[关键词]
[摘要]
目的:探讨鬼臼毒素研究现状及趋势,为将来的基础研究和临床研究提供参考。 方法:基于Citespace与R软件对科学核心集数据库(WoSCC)中关于鬼臼毒素的英文文献进行共现图谱、关键词聚类和突现分析,以此挖掘研究热点并分析前沿进展 结果:检索到来自77个国家和地区,531家机构发表关于鬼臼毒素的1220篇论文。文献发文量呈整体上升趋势。作者合作网络图谱分析表明作者之间存在合作交流但相对分散,合作并不密切,研究机构之间的关系同样存在该现象。论文数量最多的国家是中国,机构是兰州大学。869位作者参与了该领域的研究,422种学术期刊发表了关于鬼臼毒素的论文。其中鬼臼毒素、衍生物、类似物、生物评价和依托泊苷5个关键词出现频率较高,说明这些领域具有较高的关注度和较大的研究潜力。 结论:近年来鬼臼毒素及其衍生物治疗肿瘤的相关研究发展迅速。另外,鬼臼毒素的药理作用和基因调控研究亦是新的研究趋势。研究热点呈现多样化趋势,对深入探索鬼臼毒素治疗多种疾病的分子机制提供有力证据。但缺乏相对深入的基础性研究,限制了临床研究的发展。
[Key word]
[Abstract]
Objective: To explore the research status and trend of podophyllotoxin, and to provide reference for future basic research and clinical research. Methods: Based on Citespace and R software, the co-occurrence map, keyword clustering and burst analysis of the English literature on podophyllotoxin in the Scientific Core Set Database ( WoSCC ) were carried out to explore the research hotspots and analyze the frontier progress. Results: A total of 1220 papers on podophyllotoxin published by 531 institutions from 77 countries and regions were retrieved. The number of published papers showed an overall upward trend. The analysis of the author 's cooperation network map shows that there is cooperation and communication between the authors, but it is relatively scattered, and the cooperation is not close. This phenomenon also exists in the relationship between research institutions. The country with the largest number of papers is China, and the institution is Lanzhou University. 869 authors participated in the research in this field, and 422 academic journals published papers on podophyllotoxin. Among them, podophyllotoxin, derivatives, analogues, biological evaluation and etoposide have a high frequency of occurrence, indicating that these fields have high attention and great research potential. Conclusion: In recent years, the research on podophyllotoxin and its derivatives in the treatment of tumors has developed rapidly. In addition, the pharmacological effects and gene regulation of podophyllotoxin are also new research trends. The research hotspots show a trend of diversification, which provides strong evidence for further exploring the molecular mechanism of podophyllotoxin in the treatment of various diseases. However, the lack of relatively in-depth basic research has limited the development of clinical research.
[中图分类号]
[基金项目]
基金项目:国家自然科学基金委员会青年科学基金项目(82204938):基于“毒理证据链”解析八角莲致肝损伤的“证-量-毒”关系与体内毒性传递路径,负责人:刘传鑫。