脾胃湿热证是指湿热邪气侵袭脾胃,中焦气机升降失常,湿热郁蒸,脾胃生理功能失调,以脘腹痞胀,呕恶纳呆,肢体困重,便溏不爽,舌红苔黄腻,脉滑数等为主要症状的证候,多见于消化系统疾病,其中以慢性胃炎占首位。文章总结了近十年及相关领域内的研究成果,在病证结合模式下,基于方证相应原则,结合脾胃湿热证病因与病机演变,从炎症免疫状态失调、胃肠动力失常、水湿失化、内质网功能、微生态失调等多方面阐释了脾胃湿热证生物学内涵,同时以方验证,从另一角度,丰富证本质的研究。

Dampness-heat syndrome of the spleen and stomach refers to the evil dampness-heat invading the spleen and stomach, the abnormal rise and fall of the middle jiaoqi machinery, dampness-heat depression and steaming, the physiological dysfunction of the spleen and stomach, with abdominal distention and distention, nausea and lethargy of the limbs, poor loose stool, red tongue and yellow greasy fur, and slippery pulse as the main symptoms of the syndrome, most common in digestive system diseases, among which chronic gastritis is the first. This paper summarized the research results in the past decade and related fields. In the mode of combination of disease and syndrome, based on the principle of corresponding prescription and syndrome, combined with the etiology and pathogenesis evolution of spleen and stomach damp-heat syndrome, the biological connotation of spleen and stomach damp-heat syndrome was explained from various aspects such as inflammation and immune disorders, gastrointestinal motivity disorders, water and humidity loss, endoplasmic reticulum function, and micro-ecological disorders. Enrich the research of the essence of syndrome.

湖北中医药大学“双一流”建设重点类专项科研项目（2023ZZXJB003）：慢性胃炎脾胃湿热证生物学基础研究及方证效应验证；负责人：吕文亮。