随着社会的发展,近年来肥胖症的发病率逐年增高,已严重的危害了公共健康安全,是内分泌领域研究的热点。与此同时,肥胖也是导致多种代谢性疾病,如代谢综合征、糖尿病前期、高血压、多囊卵巢综合征等疾病的重要病因,但肥胖发病病因和机制尚未完全明确,关于肥胖的中西医基础研究仍需广泛开展。本文将全面总结肥胖症及其并发症的动物模型,并结合中医证候与西医机制阐述模型原理,评价其优劣性,为肥胖症的相关实验研究选择合理的动物模型提供参考。

With the development of society, the incidence of obesity has increased year by year in recent years, which has seriously jeopardized public health and safety, and is a hot spot in the field of endocrine research. At the same time, obesity is also an important cause of a variety of metabolic diseases, such as metabolic syndrome, pre-diabetes, hypertension, polycystic ovary syndrome and other diseases, but the etiology and mechanism of obesity have not been completely clear, and basic research on obesity of traditional Chinese and Western medicine still needs to be widely carried out. In this paper, animal models of obesity and its complications will be comprehensively summarized, and the model principles will be elaborated in combination with TCM syndromes and western medicine mechanisms to evaluate their merits and demerits, so as to provide references for the selection of reasonable animal models for relevant experimental studies of obesity.

中国博士后科学基金71批资助面上项目(2022MD713767):基于“脾主运化,在体合肌”理论参苓白术散激活AMPK调控铁死亡改善T2DM肌少症疗效机制研究,负责人:李品；辽宁省科学计划联合计划（2024012275-JH4/4800）：基于“虚气留滞”理论健脾渗湿法介导LKB1/AMPK/Cx43通路干预单纯性肥胖的研究机制，负责人：李品。