目的 表观遗传通过化学修饰改变DNA或蛋白质的表达，从而影响基因的调控作用，在疾病的遗传及环境因素相互作用之间扮演重要角色。本文主要探讨分析2003年-2023年溃疡性结肠炎领域表观遗传修饰的发展趋势及研究热点。 方法 从Web of Science核心合集数据库获取与UC表观遗传修饰相关的文献，采用VOSviewer、CiteSpace和R软件进行文献计量分析。 结果 共检索到2003-2023年发表的1359篇文献纳入分析。美国在表观遗传修饰领域占主导地位，芝加哥大学是发文及被引用最多的机构，Meyerhoff 炎症性肠病中心的Wu Feng是被引次数最多的作者。《Inflammatory Bowel Diseases》和《Gastroenterology》杂志具有较高影响力，筛选出UC表观遗传修饰相关的高频关键词包括micro RNA、inflammation、biomarker、azathioprine、DNA methylation、long noncoding RNA、circular RNA等受到广泛关注。 结论 表观遗传学在UC领域持续发展，对阐释UC的发病机制，在阐明遗传与环境间的相互作用上提供着重要途径，为简化诊断、改善炎症和开发新药提供新思路。

Objective Epigenetics, which changes the expression of DNA or protein by chemical modification, affects the regulation of genes and plays an important role in the interaction between genetic and environmental factors in diseases. This review focuses on the development trend and research hotspots of epigenetic modification in ulcerative colitis from 2003 to 2023. Methods Literature related to epigenetic modification in UC was obtained from the Web of Science Core Collection database, and bibliometric analyses and visualization were performed using VOSviewer, CiteSpace and R software. Results 1,359 papers published from 2003-2023 were retrieved for inclusion in the analysis. The United States dominated the field of epigenetic modification, with the University of Chicago being the most published and cited institution, and Wu Feng of the Meyerhoff Center for Inflammatory Bowel Disease being the most cited author. The journals Inflammatory Bowel Diseases and Gastroenterology have high influence, screening for high-frequency keywords related to UC epigenetic modifications, including microRNA, inflammation, biomarker, azathioprine, DNA methylation, long noncoding RNA, circular RNA, received wide attention. Conclusion Epigenetics continues to evolve in the field of UC, providing important avenues in elucidating the pathogenesis of UC, in elucidating the interactions between genetics and the environment, and in giving new ideas for simplifying diagnosis, improving inflammation, and developing new drugs.

国家自然科学基金项目（面上项目，重点项目，重大项目）；广东省自然科学基金-面上项目；省部共建中医湿证国家重点实验室专项