代谢相关(非酒精性)脂肪性肝炎（MASH/NASH)是代谢相关（非酒精性）脂肪性肝病（MAFLD/NAFLD）的一种进展性形式，以肝脏脂肪堆积、炎症、伴或不伴纤维化为特征，可进一步发展为肝硬化或肝细胞癌，是肝脏疾病中的常见病及多发病。近年来，脂质组学因其在解析脂质代谢紊乱中的独特优势，成为MASH/NASH研究的重要工具。本文综述脂质组学在MASH/NASH病理机制解析、生物标志物发现及治疗靶点探索中的作用，以期为MASH/NASH的基础研究和新药研发提供理论依据。

Metabolic (non - alcoholic)dysfunction-associated (MASH/NASH) is a progressive form of Metabolic (non - alcoholic)- associated fatty liver disease (MAFLD/NAFLD), characterized by hepatic fat accumulation, inflammation, with or without fibrosis. It can further progress to liver cirrhosis or hepatocellular carcinoma, and is a common and frequently - occurring liver disease. In recent years, due to its unique advantages in analyzing lipid metabolism disorders, lipidomics has become an important tool in the research of MASH/NASH. This article reviews the role of lipidomics in elucidating the pathological mechanisms of MASH/NASH, discovering biomarkers, and exploring therapeutic targets, aiming to provide a theoretical basis for basic research and new drug development for MASH/NASH.

国家自然科学(82160866)：祛脂愈肝方通过JAK-STAT信号介导的TH17/Treg平衡治疗非酒精性脂肪肝炎的作用机制研究,负责人：杨梅。